Title: miR Seekers: Finding Targets of MicroRNAs in Undergraduate Lab Courses
Url: http://www.ableweb.org/volumes/vol-37/v37reprint.php?ch=8
Author: Irene Munk Pedersen
Adam Idica
Pavan Kadandale
Jordan Thompson
Author's Address: University of California - Irvine, Department of Molecular Biology and Biochemistry, Irvine, CA
Email Address: pavan.k@uci.edu
Description: MicroRNAs (miRs) are small, non-coding RNAs that regulate gene expression programs critical for normal
development and health. Misregulation of miRs are associated with numerous diseases, and miRs are
currently being investigated both as drug targets, and as potential therapeutics. The techniques used to
validate miR target predictions are relatively straightforward and inexpensive, making this an ideal vehicle to introduce students in undergraduate labs to authentic research experiences. We describe here a 3-session lab module that we have developed that allows students to generate hypotheses about specific miR candidates, and then design and execute experiments to test their predictions.
Keywords: microRNA
research-based laboratories
molecular biology
miRNA
Topic: Molecular Biology
BEN Subject/Discipline Taxonomy: Molecular Biology
Learning Resource Type: Laboratory exercise (DCMI Type Vocabulary)
Context: Undergraduate upper division 15-16
Format: pdf
Access Rights: This resource is for ABLE members only.
Rights: http://www.ableweb.org/copyright-policy/
Conference Location & Year: Boston University (2015)
Cumulative Rating: NOT YET RATED
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