Association for Biology Laboratory Education

Modeling Gene Circuits
    

Ann Yezerski

Advances in Biology Laboratory Education, 2025, Volume 45

https://doi.org/10.37590/able.v45.abs40

Abstract

One of the current trending terms in molecular biology is ?gene circuit? which refers to the genetic control of intricate enzymatic pathways that are responsible for biochemical processes in the body. The more we learn about the molecular genetics and physiology of these pathways, the more difficult it is for students to conceive of all the interactions. To make these complex concepts more understandable, I have created an exercise using electrical circuits as analogs. Since electrical circuits can be just as complicated to understand as genetic pathways, I use Snap Circuits (Elenco? #SC100 or SC300), a child?s educational toy kit designed to teach electronics.. Through use of Snap Circuits, students model pathways being studied in class and build their own gene circuits for a chosen biochemical process. An example will be presented which applies the concepts to the classic Drosophila eye pigments laboratory exercise. Participants will construct their own basic pathways and discuss options for use in courses such as Genetics, Biochemistry, and Cell Biology.

Keywords:  gene circuits, biochemical pathways, enzymes, Drosophila eye pigments

University of Maryland (2024)