Dog genomes reflect the consequences of selective breeding and intentional genetic isolation. We share many of the same diseases with our canine companions but finding the genes in dogs is faster and more efficient due to their unique genome structures. Many canine characteristics, such as coat length, color and curl map to specific genes. In this session, participants will learn how to guide students through a basic Genome-Wide Association Study (GWAS) by engaging with authentic datasets to identify associations between single nucleotide polymorphisms and canine traits. SNPs serve as signposts for genes but can influence traits through direct or indirect genetic mechanisms. We will model to explore how an indirect genetic change can have phenotypic consequences, by focusing on RSPO2?a gene that influences the development of whiskers and eyebrows (furnishings). In this activity, which can be used in the lab as a precursor to other DNA and genetic studies, students focus on a specific gene to model how an indirect genetic change can impact physical traits. Participants will explore ways to support and deepen student engagement in groupwork through guided reflection.
Keywords: genomics, dog, GWAS, SNP
University of Manitoba (2025)
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