In this two-week lab exercise students develop a more mechanistic understanding of the relationship between genotypes and phenotypes by working with the interactions between genes, enzymes, metabolic pathways, and organismal-level phenotypic traits. After exploring these relationships in yeast, students learn to explore the implications of their experiments, and to appreciate the value of model organisms by extending their conclusions from yeast to humans. During the workshop, participants will conduct the experiment to mate haploid yeast strains and will be provided with the results of such matings. We will discuss how this experiment relates to the central dogma of biology, biochemical genetics, mutations, genotypes and associated phenotypes, and the use of model organisms in biological research. Multiple student assignments associated with this experiment will be presented.
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