Regulation of Blood Glucose Levels in Normal and Diabetic Rats

 

Linda Butler

Tested Studies in Laboratory Teaching, 1995, Volume 16

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Abstract

This exercise demonstrates the crucial role insulin plays in blood glucose homeostasis in mammals. Three pairs of fasted rats are tested in each of three different regimes; one rat of each pair is normal and the other is diabetic. The first pair is administered an oral glucose load and a placebo injection of saline. The second pair is administered an oral glucose load and an insulin injection. The third pair is administered an oral placebo of water and a placebo injection of saline. The blood glucose levels of the six rats are monitored at 20-minute intervals for 2 hours by taking blood samples from each rat’s tail.

Keywords:  blood glucose, insulin, glucose tolerance test, homeostasis, diabetes

Emory University (1994)

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